Appendix Table 2.

Adjusted Hazard Ratios From Sensitivity Analyses for Ozone and Fine Particulate Matter Exposures, Including Subjects With Cancer, Myocardial Infarction, or Stroke, Nurses’ Health Study, United States, 1996–2008

Outcome	No. of Cases	Person Years	Per 10-ppb Increase in Summera Ozone Concentration		Per 10-μg/m3 Increase in 1-year PM2.5 Concentration
			HRb	95% CI	HRb	95% CI
Antidepressant use or depression diagnosis	6,627	465,165	1.03	0.98, 1.08	1.06	0.96, 1.16
Depression diagnosis	3,205	485,497	1.01	0.94, 1.08	0.96	0.84, 1.10
Use of antidepressant medication	5,989	469,752	1.04	0.99, 1.10	1.08	0.98, 1.19

Abbreviations: CI, confidence interval; HR; hazard ratio; PM_2.5, particulate matter with an aerodynamic diameter less than or equal to 2.5 μm; ppb, parts per billion.

^a Summer was defined as May–September.

^b All models adjusted for calendar year, month at questionnaire return, census region, living in a Metropolitan Statistical Area, race, physical activity, body mass index, pack-years of smoking, smoking status, dietary habits, alcohol consumption, multivitamin intake, participation in social groups, baseline abbreviated Mental Health Inventory score, educational level, parental education, marital status, husband's education (if applicable), tract-level median income, house value, and population density.