Figure 2.

Schematic representation of SETD2 and cancer-associated mutations. SETD2 domains: AWS (associated with SET), SET (Su(var)3-9, enhancer-of-zeste, trithorax), PS (post-SET), CC (coiled coil), LCR (low charge region), WW, SRI (Set2 Rpb1 Interacting). Mutation lists were obtained from CBioPortal on February 5, 2016, and separated into cancer types. Duplicates were removed. Mutations are plotted by color (cancer type) and shape (mutation type). ccRCC, Clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma.