Table 1.

Subtype distribution of the most mutated genes in diffuse large B-cell lymphoma (DLBCL) (see also Fig. 1)

Gene	Total (%)a	ABC (%)b	GCB (%)	Functional characterization of gene mutations in DLBCL
KMT2D	32.1	40.5	46.0	Ortega-Molina et al. 2015; Zhang et al. 2015
CREBBP	17.3	6.0	31.0	Pasqualucci et al. 2011a
PIM1	16.4	33.0	8.5	Kumar et al. 2005; Peters et al. 2016
TP53	15.7	18.0	15.5	–
B2M	14.7	8.5	18.0	Challa-Malladi et al. 2011
TNFAIP3	14.7	15.0	11.0	Compagno et al. 2009; Honma et al. 2009
GNA13	14.1	8.5	12.0	Muppidi et al. 2014
MYD88	13.7	28.0	10.0	Ngo et al. 2011
MEF2B	13.5	12.0	23.0	Pon et al. 2015; Ying et al. 2013
TNFRSF14	12.8	2.0	17.0	Boice et al. 2016
SOCS1	11.8	6.0	15.5	–
CD79B	11.3	25.0	2.5	Davis et al. 2010
CARD11	10.8	13.5	7.0	Lenz et al. 2008a
BCL2	10.6	1.0	24.0	Schuetz et al. 2012
EP300	10.4	15.0	14.5	Pasqualucci et al. 2011a
PRDM1	9.6	16.0	6.0	Calado et al. 2010; Mandelbaum et al. 2010
EZH2	9.2	0.0	18.0	Béguelin et al. 2013; Velichutina et al. 2010
CD58	8.3	6.0	10.0	Challa-Malladi et al. 2011

ABC, activated B-cell-like; GCB, germinal center B-cell-like.

^aMutation frequencies were pooled from Pasqualucci et al. 2011b; Lohr et al. 2012; Morin et al. 2013; Dubois et al. 2016. All subentities were included.

^bMutation frequencies in ABC only or GCB only from Dubois et al. 2016.