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Two models that explain the observed allelic fractions of the USP8 and RASD1 somatic mutations. (A) Mutation RASD1 p.K34M occurs in a single cell derived from the clonal expansion of USP8-mutant cells. (B) Mutation RASD1 p.K34M occurs in an independent, USP8-wild-type cell and undergoes clonal expansion separate from the USP8-mutant clonal expansion.
