Figure 1.
Cellular signaling domains mediating the generation of circadian rhythms in suprachiasmatic nucleus neurons. Molecular timekeeping signals generated in the nucleus are transmitted via intracellular signaling pathways to alter the activity of ion channels located in the neuronal membrane. Changes in the membrane electrical potential are communicated back to the molecular clock to synchronize and stabilize molecular rhythms. NACLN, Voltage-insensitive nonselective cation channel; cAMP, cyclic adenosine monophosphate; BKCa, large conductance calcium-activated potassium channel; ICa, voltage-gated calcium channels; IH, hyperpolarization-activated channel; K2P, two-pore domain potassium channel; TASK, TWIK (two-pore domain weak inward rectifying potassium channel)-related acid-sensitive K+ channel; TREK, TWIK-related potassium channel; FDR, fast delayed rectifier.