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. 2017 May;27(5):801–812. doi: 10.1101/gr.213462.116

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© 2017 Edge et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Comparison of runtime (top panel) and switch + mismatch error rate (bottom panel) for HapCUT2 with four methods for haplotype assembly (HapCUT, RefHap, ProbHap, and FastHare) on simulated read data as a function of (A) mean coverage per variant (variants per read fixed at four); (B) mean variants per read (mean coverage per variant fixed at five); and (C) mean number of paired-end reads crossing a variant (mean coverage per variant fixed at five, read length 150 bp, random insert size up to a variable maximum value). Lines represent the mean of 10 replicate simulations. FastHare is not visible on C (bottom) due to significantly higher error rates.