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. 2017 Apr 1;7(4):784–800.

Figure 3.

Figure 3

miR-1468-5p directly and negatively regulates RRM1 in glioma cells. A: The miR-1468-5p binding sites in the 3’UTR of RRM1 with the wild type (Wt) and mutated (Mut) sequences highlighted. B: Western blot analysis of RRM1, p-AKT, AKT, p-ERK1/2 and ERK1/2 in U87 and U251 cells after transduction with miR-ctrl or miR-1468-5p. C: U87 and U251 cells were co-transfected with miR-1468-5p and luciferase reporter constructs containing either pGL3-RRM1-3’-UTR-WT or pGL3-RRM1-3’-UTR-Mut; **P<0.01.