Cell growth was significantly affected by p62/SQSTM1 status under irradiation in hypopharyngeal carcinoma cells, but not under CDDP exposure. The growth of FaDu and D562 carcinoma cells treated with shRNA (sh-control, sh-p62 (1) and (2)) was evaluated with/without X-ray irradiation (A) or CDDP exposure (B). (A) Upper and lower panels indicate the data on FaDu and D562 cells; *, P < 0.05, to sh-control cells, one-way factorial ANOVA accompanied by Scheffe’s significance test. (B) Left and right graphs indicate the data on FaDu and D562 cells. Sh-control (blue), sh-p62 (1) (red) and (2) (green).