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p62/SQSTM1 knockdown affected Nrf2-Keap1 pathway under X-ray irradiation. Under X-ray irradiation (left panels), the contents of Nrf2 and HO-1 were especially decreased in p62/SQSTM1 knockdown (sh-p62 (1) and (2)) cells, and those of NQO1 were moderately decreased. CDDP exposure (right panels) caused dose-dependently reduction of HO-1, Nrf2 and/or NQO1, regardless of the differences of p62/SQSTM1 status. Keap1 was abundantly detected in almost all the experimental conditions.
