Figure 3.

Synergistic induction of G2/M phase cell cycle arrest of 8305C cells by lenvatinib and paclitaxel. Cells were treated with vehicle control or lenvatinib and paclitaxel at the indicated concentrations, individually or in combination, for 48 h. DNA content was then measured by flow cytometry to determine cell cycle fractions. Representative flow cytometric histograms are shown in the left panel. The percentage of 8305C cells in the G2/M phase is indicated in the right panel. Statistically significant differences are indicated: **, P < 0.01; ***, P < 0.001 for comparison with control; ▲, P < 0.05 for comparison with paclitaxel monotherapy; ##, P < 0.01 for comparison with lenvatinib monotherapy.