Figure 2.

Drug sensitivity of NF1 and NF2 cell lines. Heatmap of drug IC50s in seven NF1-associated MPNST cell lines (ST88-14, ST88-3, 90-8, sNF02.2, T265, S462TY, SNF96.2), one sporadic MPNST cell line (STS26), one schwannoma from a NF2 patient (HEI193), one NF2-deficient malignant meningioma (KT21-MG-Luc5D), one mouse NF2 schwannoma (SC4) and one sporadic rat schwannoma (RT4). The IC50s were determined from eight drug concentrations and expressed as a heatmap. Drugs are segregated by drug target. Experiments were repeated at least twice for all cells except S462TY. The most active compounds are blue, while compounds in red are less active. Inactive compounds were assigned an IC50 of 25 μM (eg. ≥ 25 μM), and highly active compounds were assigned an IC50 of 0.001 μM (eg. IC50 ≤ 0.001 μM).