Table 1.
Dosing schedules
| Model | LU342 | PC-9 | LU858 | DCFI08 | HCC827-GR-T790M |
|---|---|---|---|---|---|
| Treatment (days) | 22 | 70 | 12 | 18-21 | 32 |
| Observation period (days) | 78 | 128 | 46 | 80 | 60 |
| Tepotinib 100 mg/kg | (5+2) w | (5+2) w | (5+2) w | Daily | Daily |
| Cetuximab 50 mg/kg | 3×1 w | - | - | - | - |
| Erlotinib 20 mg/kg | (5+2) w | - | - | Daily | Daily |
| Gefitinib 150 mg/kg | (5+2) w | - | (5+2) w | - | - |
| Afatinib 5 mg/kg | (5+2) w | (5+2) w | (5+2) w | Daily | Daily |
| Rociletinib 10 mg/kg | - | - | Daily | Daily | |
| Erlotinib + tepotinib 20/100 mg/kg | (5+2) w | - | - | Daily | Daily |
| Gefitinib + tepotinib 150/100 mg/kg | (5+2) w | - | (5+2) w | - | - |
| Afatinib + tepotinib 5/150 mg/kg | (5+2) w | (5+2) w | (5+2) w | Daily | Daily |
| Rociletinib + tepotinib 10/150 mg/kg | - | - | - | Daily | Daily |
(5+2) w, treated for 5 days, untreated for 2 days of each week. 3×1 w, three weekly doses.