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. Author manuscript; available in PMC: 2018 Mar 15.

Published in final edited form as: Eur J Pharmacol. 2017 Feb 10;799:128–134. doi: 10.1016/j.ejphar.2017.02.016

Fig 4 — A: Neurons were subjected to 3, 6 and 9 h of OGD followed by 6 h of reoxygenation which lead to >2 fold increase in LDH assay. C21 did not affect LDH release into the supernatant. N=3. *P<0.05 vs Normoxic control.

B: C21 in 100 and 1000 nM concentrations decreased cleaved caspase 3 as measured by western blotting in cell lysate. N=3. *P<0.05 vs respective 100, 1000 nM groups and normoxic control. ^#P<0.05 vs respective 100, 1000 nM groups and normoxic control.

C: C21 anti-apoptotic effect is mediated through AT2R stimulation. C21 anti-apoptotic effect was blocked by PD123319 but not anti-IL-10 neutralizing antibody. N=3. *P<0.05 vs normoxic control, 100 nM, 100 nM, and 100nM+IL-10_Ab.

Fig 4 — A: Neurons were subjected to 3, 6 and 9 h of OGD followed by 6 h of reoxygenation which lead to >2 fold increase in LDH assay. C21 did not affect LDH release into the supernatant. N=3. *P<0.05 vs Normoxic control.

B: C21 in 100 and 1000 nM concentrations decreased cleaved caspase 3 as measured by western blotting in cell lysate. N=3. *P<0.05 vs respective 100, 1000 nM groups and normoxic control. ^#P<0.05 vs respective 100, 1000 nM groups and normoxic control.

C: C21 anti-apoptotic effect is mediated through AT2R stimulation. C21 anti-apoptotic effect was blocked by PD123319 but not anti-IL-10 neutralizing antibody. N=3. *P<0.05 vs normoxic control, 100 nM, 100 nM, and 100nM+IL-10_Ab.