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. 2017 Apr 15;9(4):1543–1560.

Figure 5.

Figure 5

Exosome-melatonin treatment on preservation of hepatocyte and liver histological integrity 72 hours after reperfusion. (A to E) Hematoxylin and eosin (H&E) staining (100 x) for assessing hepatic damage at 72 hour after reperfusion. Note remarkable histological damage (bound by yellow dotted lines) in animals without exosome (Ex)-melatonin (Mel) treatment (B) compared to that in sham-operated controls (A) and in animals having received treatment with Ex (C), Mel (D) or Ex-Mel (E). Scale bars at right lower corners represent 100 µm. (F) Liver injury scores of different groups, * vs. other groups with different symbols (†, ‡, §, ¶), P<0.0001. (G) Circulating level of aspartate aminotransferase (AST), * vs. other groups with different symbols (†, ‡, §, ¶), P<0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 10 for each group). Symbols (*, †, ‡, §, ¶) indicate significant differences (at 0.05 level). SC = sham control; LIR = liver ischemia reperfusion; Ex = exosome; Mel = melatonin.