Figure 2.

Melatonin significantly improved oxidative stress and apoptotic damage. A. Melatonin reduced serum and ovarian homogenates MDA level and MDA5 expression in the ovaries. B. Melatonin decreased the protein and mRNA expression of Gp91^phox. C. Melatonin increased serum and ovarian homogenates TAC levels. D. Melatonin increased SOD expression. E. Melatonin increased GSH-Px expression. F. Melatonin reduced Caspase3 expression. G. Melatonin decreased Bax expression. H. Melatonin increased Bcl-2 expression. Data were shown as mean ± SEM or as ratio. *P<0.05, **P<0.01, ***P<0.001.