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Melatonin receptor antagonist luzindole significantly suppressed SIRT1 signaling pathway. A and B. Luzindole reduced the protein and mRNA levels of SIRT1. C and D. Ex527 increased the protein and mRNA levels of FoxO3a. E and F. Ex527 reduced the protein and mRNA levels of Nrf2. G and H. Ex527 decreased the protein and mRNA levels of Ho-1. Data were shown as mean ± SEM or as ratio. *P<0.05, **P<0.01, ***P<0.001.
