Figure 1.

ISA pre-conditioning reduces brain edema and infarction volume. ISA pre-conditioning was administered to rats in the ischemic model described in the Methods. Animals were sacrificed at 12, 24, and 48 h to evaluate edema and infarction damage. A. Average brain weight of rats in different groups; no significance was observed. B. Average body weight of rats in different groups; no significance was observed. C. Brain water content in different groups at 12, 24, and 48 h. D. Brain infarction rate in different groups at 12, 24, and 48 h. Data in the figures represent the average ± SD (n = 3). *P < 0.05, compared to the control group; #P < 0.05, compared to the 12 h group.