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. 2017 Apr 15;9(4):1810–1821.

Figure 3.

Figure 3

MLN4924 inhibits the expression of pro-inflammatory cytokines and chemokines in vitro. A, B. Determination of iNOS mRNA expression and NO production in LPS (1 μg/ml)-treated RAW264.7 cells, together with MLN4924 (0.5 μM) or PBS treatment for 24 hrs. C-E. Relative mRNA levels of IL-1β, TNFα and MCP-1 in LPS (1 μg/ml)-treated RAW264.7 cells, together with MLN4924 (0.5 μM) or PBS treatment for 12 hrs. F-H. Relative mRNA levels of IL-8, CXCL5 and KC in an A549 cell line treated with IL-1β (10 ng/ml) and MLN4924 at the indicated doses for 24 hrs. Error bars represent the mean ± SD, representative of three experiments, *P < 0.05.