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. 2017 Apr 15;9(4):1866–1875.

Figure 4.

Figure 4

Curcumin converts Cca patient-derived Tregs to Th1 cells. CD4+ CD25+ CD127- T cells were isolated from PBMC (from 10 Cca patients) by MACS (A, B). The cells were cultured in the presence of curcumin (10 mM) for 6 days, and then analyzed. (C, D) The gated histograms indicate the frequency of IFN-γ+ cells. (E) The bars are the summarized data of (C, D). (F) The bars indicate the mRNA levels of IFN-γ. (G) The immune blots indicate the protein levels of IFN-γ. (H, I) The gated histograms indicate the frequency of Foxp3+ cells. (J) The bars are the summarized data of (H, I). (K) The bars indicate the mRNA levels of IFN-γ. (L) The immune blots indicate the protein levels of IFN-γ. The data of bars are presented as mean ± SD. *, P<0.01, compared to the medium group. The data are summarized from 3 independent experiments.