Figure 1.

CXCR4-siRNA and/or CXCR7-siRNA inhibit tumor growth in vivo. A. Macroscopic appearance of tumors in nude mice following the completion of therapy. Arrows outline the representative tumors in the right scapular region of the mice. B. Images of representative excised tumors from each group. C. Tumor volumes were averaged for each treatment group and time point over the course of the study (mean ± SD). D. Final tumor weights of the isolated tumors were averaged for each group (mean ± SD). CX4-si, CXCR4-siRNA treatment; CX7-si, CXCR7-siRNA treatment; CX4/CX7-si, CXCR4-siRNA in combination with CXCR7-siRNA treatment; Ne-si, Negative-siRNA treatment; NS, normal saline.