Table 3. The pharmacokinetic parameters of different DPI formulations in the plasma (n = 4). Data were reported as mean ± SD.
| Formulations | Cmax (ug/ml) | Tmax (min) | AUC0-8h (ug·h/ml) | AUC0~∞_D (g·h/ml) | MRT0-8h (min) | T1/2 (min) |
|---|---|---|---|---|---|---|
| M0 | 1.37 ± 0.06 | 10 | 1.11 ± 0.11 | 2.64 ± 0.49 | 96.89 ± 11.70 | 90.68 ± 5.11 |
| M4 | 1.74 ± 0.12* | 10 | 1.57 ± 0.13*,# | 1.84 ± 0.15 | 79.05 ± 3.78* | 156.04 ± 16.30* |
| Pulmicort | 1.59 ± 0.14 | 10 | 1.30 ± 0.07 | 0.51 ± 0.04 | 79.46 ± 7.80* | 169.87 ± 10.99* |
Comparison between groups was done by one way AVOVA followed by Bonferroni post hoc test.
*p < 0.05 vs. M0 and #p < 0.05 vs. Pulmicort.