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(A) Lowest-energy docking poses of angusticornin B (green), balsacone C (yellow), caffeoyl-p-coumaroyltartaric acid (aqua), and curcumin II (magenta) with DENV helicase (PDB 2JLX) [26]. (B) Curcumin II in the active site of DENV helicase (PDB 2JLX) showing key intermolecular contacts (hydrogen-bonds are shown as blue dashed lines). The ADP co-crystallized ligand is shown as a yellow wire figure.
