Table 6.

Sensitivity analysis 2: Risk factors associated with acute kidney injury multivariable model with ICD10-N17 or N19 code for outcome (N = 3471 outcome = 373)

Characteristics		Model from primary analysisa OR (95% CI)	P valueb (PT)	Sensitivity analysis Odds Ratioa (95% confidence interval)	P valueb (PT)
Females		0.64 (0.49–0.83)	0.0008	0.63 (0.49–0.80)	0.0002
Age categories years	65–69	0.83 (0.52–1.35)	0.55	1.00 (0.65–1.54)	0.52
	70–74	0.70 (0.46–1.09)		0.75 (0.50–1.11)
	75–79	0.78 (0.54–1.13)		0.82 (0.58–1.15)
	80–84	0.84 (0.59–1.18)		0.90 (0.66–1.23)
	≥85	1		1
Smoking status	Non-smoker	1	0.25	1	0.32
	Current smoker	1.39 (0.92–2.11)		1.32 (0.91–1.92)
	Ex-smoker	1.26 (0.91–1.74)		1.19 (0.89–1.59)
Alcohol intake (units/day)	Non-drinker	1	0.43	1	0.18
	Ex-drinker	1.00 (0.64–1.55)		1.17 (0.78–1.76)
	Current ≤6 units/day	0.88 (0.61–1.26)		0.99 (0.71–1.39)
	Heavy >6 units/day	0.55 (0.24–1.26)		0.54 (0.25–1.16)
BMI (kg/m2)	15–18.4	0.95 (0.45–2.00)	0.53	0.80 (0.40–1.61)	0.28
	18.5–24.9	1		1
	25–29.9	0.90 (0.65–1.23)		0.84 (0.63–1.11)
	≥30	1.14 (0.82–1.58)		1.10 (0.81–1.47)
eGFR (mL/min/1.73m2)	≤29	4.62 (3.06–6.99)	<0.0001	4.86 (3.34–7.09)	<0.0001
	30–59	2.48 (1.84–3.33)	(<0.0001)	2.47 (1.89–3.23)	(<0.0001)
	≥60	1		1
Proteinuria		1.23 (0.95–1.59)	0.12	1.22 (0.96–1.54)	0.10
Hypertension		1.27 (0.93–1.73)	0.13	1.19 (0.90–1.57)	0.21
Congestive cardiac failure		1.03 (0.76–1.39)	0.86	1.05 (0.80–1.39)	0.71
Ischaemic heart disease		0.76 (0.58–1.00)	0.04	0.77 (0.60–0.98)	0.03
Cerebrovascular disease		0.90 (0.68–1.20)	0.47	0.81 (0.62–1.05)	0.10
Dementia		1.17 (0.73–1.88)	0.53	1.17 (0.76–1.82)	0.48
Chronic lung disease		0.79 (0.58–1.07)	0.12	0.75 (0.57–0.98)	0.03
Cancer		0.76 (0.54–1.07)	0.11	0.89 (0.66–1.19)	0.42
Connective tissue diseases		0.66 (0.40–1.08)	0.08	0.73 (0.47–1.12)	0.14
Either ACEI/ ARBs		1.59 (1.19–2.13)	0.002	1.48 (1.14–1.92)	0.003
Glycated haemoglobin levels	Good <7%	1		1
	Borderline 7–10%	0.82 (0.62–1.09)	0.38	0.85 (0.66–1.10)	0.42
	High >7%	0.82 (0.43–1.54)		1.03 (0.60–1.77)
Medication-diabetes	None	1		1
	Oral	1.05 (0.75–1.46)	0.05	1.02 (0.75–1.38)	0.02
	Insulin	2.27 (1.27–4.05)		2.27 (1.34–3.84)
	Both	1.11 (0.72–1.71)		1.10 (0.74–1.62)
Study period	April 2004–September 2007	1	<0.0001	1	<0.0001
	October 2007–March 2011	2.90 (2.14–3.95)	(<0.0001)	2.38 (1.83–3.10)	(<0.0001)

^aadjusted for all variables in table BMI body mass index eGFR estimated glomerular filtration rate ACEI angiotensin converting enzyme inhibitors ARBs angiotensin II receptor blockers^b likelihood ratio test P_T P value for trend