Table 1. Reduced neurite growth of N2a cells with KDM5C patient mutations.

Percentage of cells with neurites and total neurite length per cell were measured after 24 hrs of retinoic acid treatment, shown below as mean ± standard error. Six independent samples per cell line were examined.

Cell Line	% Cells with Neurites	Total Length of Neurites (μm)
GFP	68.17 ± 2.6*	54.9 ± 6.2
WT	58.5 ± 3.3	55.1 ± 3.4
D87G	51.1 ± 2.6	59.7 ± 5.4
A388P	49.8 ± 3.6	57.9 ± 3.4
H514A	48.1 ± 3.3*	37.1 ± 4.1*
F642L	36.6 ± 1.5**	47.3 ± 3.6
Y751C	27.9 ± 3.9**	35.2 ± 5.5*

^*p< 0.05,

^**p <0.0001, t-test relative to cells transfected with wild type KDM5C (WT).