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. 2017 Apr 17;2017:8073721. doi: 10.1155/2017/8073721

Figure 1.

Figure 1

Drp1 regulation by phosphorylation. Phosphorylation of Ser579 by Cdk1 [9, 44], Pkcδ [45], Erk1/2 [46, 47], or Cdk5 [48] induces mitochondrial fission. Phosphorylation of Ser656 by Gsk3β [49] induces mitochondrial fusion. Phosphorylation of Ser600 by Pka [15, 52, 53], CamkII [48], or Ampk [55] induces mitochondrial fusion, and its dephosphorylation by calcineurin (CaN) [53, 54] induces mitochondrial fission, but, in some circumstances, phosphorylation of Ser600 by CamkI [50] or RockI [51] can induce mitochondrial fission.