Table 3.

Summary of phage-encoded endolysins tested in vivo.

Target pathogen	Endolysin	Animal model	References
Acinetobacter baumannii	PlyF307	Bacteraemia	[97]
Bacillus anthracis	PlyG PlyPH	Sepsis Peritonitis	[98, 99]
Pseudomonas aeruginosa	LoGT-008 (Artilysin)	Gut decolonization	[100]
Staphylococcus aureus	ClyS λSa2-E-lyso-SH3b LysK/CHAPk LysGH15 MV-L PhiSH2 Phi11 PlySs2 Ply187AN-KSH3b SAL-1 Twort WMY 80α 2638A	Nasal decolonization Bacteraemia Sepsis Mastitis Endophthalmitis	[101–111]
Streptococcus agalactiae	PlyGBS/PlyGBS90–1 PlySK1249	Vaginal decolonization Oropharynx decolonization Bacteraemia	[112–114]
Streptococcus pneumonia	Cpl-1 Cpl-771 PAL	Bacteraemia Sepsis Endocarditis Meningitis	[115–120]
Streptococcus pyogenes	PlyC (formerly C1) PlyPy PlySs2	Oral decolonization Bacteraemia	[84, 97, 106]