Table 2.
Cytotoxicity of Strychnos spinosa leaf extracts and fractions from leave on Macrophage U937 cells their selectivity index (SI).
| Extracts | LC50 (μg/ml) | Selectivity Index (LC50/IC50) |
|---|---|---|
| AcetE | 27.36±0.85 | 0.084 |
| MetE | 100. 91±0.03 | 0.508 |
| DCM/MetE | 31.41±0.34 | 0.271 |
| ALKE | 92. 62±0.27 | 0.308 |
| Fractions | ||
| WatF | 50.00±0.08 | 0.565 |
| nButF | 98.75±0.00 | 0.438 |
| EtAcf | 162.42±0.00 | 0.216 |
| ChlF | 37.38±0.08 | 0.386 |
| HexF | 143.21±0.00 | 0.476 |
| Controls | ||
| Quercetin | nd | Nd |
| Doxorubicin | 4.59±0.01 | Nd |
AcetE: Acetone extract, MetE: Methanol extract, DcmMetE: Dichloromethane/methanol extract, AlkE: Alkaloids extract, HexF: n- hexane fraction, ChlF: Chloroform fraction, EtAcF: Ethyl acetate fraction, nBuF: n-Butanol fraction, WatF: Water fraction, nd: not determined.