Figure 4.

Differences showing the effects of stress/antidepressant treatments on the expression levels of hippocampal PKA-α, CREB, and p-CREB in depression rats induced by CUMS. (a) The effects of stress/antidepressant treatments on the expression level of hippocampal PKA-α in depression rats induced by CUMS. (b) The effects of stress/antidepressant treatments on the expression level of hippocampal CREB in depression rats induced by CUMS. (c) The effects of stress/antidepressant treatments on the expression level of hippocampal p-CREB in depression rats induced by CUMS. Differences are shown as follows: ^★★P < 0.01 versus control group; ^▲P < 0.05 versus model group; ^▲▲P < 0.01 versus model group; ^◆◆P < 0.01 versus acupuncture group; ^■■P < 0.01 versus fluoxetine group. Results are presented as $\overline{x}\pm s$ for 10 rats in each group. Acu: acupuncture group; FLX: fluoxetine group; Acu + H89: Acupuncture + H89 group; FLX + H89: Fluoxetine + H89 group; PKA-α: protein kinase A-α; CREB: cyclic adenosine monophosphate response element-binding protein; p-CREB: Phosphor-CREB; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.