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. 2017 Mar 1;14(3):218–230. doi: 10.21010/ajtcam.v14i3.24

Figure 5.

Figure 5

Effect of C. ficifolia extract (200 mg/kg/day, equivalent to 11.6 μg/kg/day of p-coumaric acid) or metformin (50 mg/kg/day) on liver enzymes content in sub-chronic study: A) ALT; B) AST. Mean±S.E.M. (n=5). *Significant difference against Normal control; *Significant difference against diabetic control (Alloxan ISS). p<0.05. C-F) Photomicrographs of liver transversal section: C) Control mice (ISS); D) Alloxan-diabetic mice treated with ISS; E) Alloxan-diabetic mice treated with C. ficifolia. F) Alloxan-diabetic mice treated with metformin. Hepatocyte (H), central vein (CV), hepatic cord (reversible arrow), sinusoid (S), hepatic lobule (dashed line), hyperemia (arrow head), vascular congestion (unfiled arrow), karyorrhexis (arrow) and hydropic degeneration (#). (H&E, original magnification main 100x and box 400x).