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The effects of GL treatment on the production of HMGB1 and proinflammatory cytokines after CLP. Rats received 10 mg/kg of GL for 3 days after CLP or sham surgery. The plasma levels of HMGB1 (a), TNF-α (b), IL-1β (c), and IL-6 (d) were determined at 0, 12, 30, and 60 h after CLP. Data are presented as means ± SEM. n = 6 rats/group. ∗p < 0.05 compared with sham control.
