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. 2017 Mar 23;18(4):622. doi: 10.3390/ijms18040622

Figure 6.

Figure 6

Correlation between the aneuploidy of CTCs and the prognosis. DAPI: blue; CD45: red; CEP8: red; CK18: green. (A) A monoploid CTC (orange arrow) and WBC (red arrow) isolated from one PC patient; (B) A non-hematopoietic triploid CTC is indicated by the orange arrow. A diploid WBC stained with weak CD45 is marked by the red arrow; (C) A tetraploid CTC is indicated by the orange arrow and the other one stained by CD45 is a WBC; (D) A multiploid CTC is indicated by the orange arrow. The other two cells stained by CD45 were WBCs; (E) The distribution of triploid and tetraploid numbers in the control group and PC group were statistically significant (p < 0.001, p = 0.0204), but not in the multiploid group (p = 0.0557); (F) One-year survival was significantly relevant to the counts in the triploid group (hazard ratio for death, 0.3941; 95% CI 0.1144 to 0.8783 p = 0.0279). The triploid CTC < 3 group had a median overall survival of 13 months longer than the triploid CTC ≥3 group (6.03 months; hazard ratio for death, 0.4309; 95% CI 0.1374 to 0.8219 p = 0.0188). The black dashed line indicates the median. Scale bar = 5 µm.