Figure 2.

BCP treatment diminishes EAE severity and ameliorates weight loss after immunization. Daily clinical score (a), cumulative score (b), and animal body weight (c) were analyzed in the naive group, EAE group, and in animals under prophylactic treatment with (−)-β-caryophyllene (25 or 50 mg/kg, oral route—p.o.—daily, twice/day) during the entire experiment (from day 0 to 30 post-immunization). Data points are presented as the mean ± SEM (n = 6–8 animals per group and are representative of two independent experiments). ^## p < 0.001 vs. naïve group, and ** p < 0.001 vs. EAE-group (one-way ANOVA followed by Bonferroni’s post hoc test).