Table 1.

Long non-coding RNAs associated with cell proliferation of osteosarcoma.

LncRNA Name	Expression in OS	OS Cells	Potential Mechanism	Tumor Cell Proliferation	Ref.
TUG1	High	U2OS cells	Inhibit apoptosis	Promote	[55]
		U2OS and Saos-2 cells	TUG1/miR-9-5p/ POU2F1 pathway		[56]
H19	High	Kios5 cells	Hh signaling pathway and the oncogene Yap1	Promote	[52]
HIF2PUT	Low	SAOS2, MG63, U2OS and OS-732 cells	Control HIF-2α expression	Inhibit	[57]
BANCR	Low	MG63 cells	JNK and Wnt/β-catenin signaling pathway	Inhibit	[54]
MALAT1	High	U2OS and Saos2 cells	PI3K/AKT signaling pathway	Promote	[53]
		Saos2, MG63, U2OS cells	Target TGFA promotion via Inhibiting MIR376A		[58]
		U2OS, HOS, 143B and MG63 cells	Increase RhoA and its downstream effectors ROCKs		[59]
HOTAIR	High	U2OS, HOS, 143B and MG63 cells	Activate MMP2 and MMP9	Promote	[60]
		MG63 cells	Upregulate TGF-β and Bcl-2, upregulate p53 and TNF-α		[61]
HOTTIP	High	MG-63 and HOS cells	-	Promote	[62]
ANCR	High	U2OS and Saos2 cells	Related to p21,CDK2	Promote	[63]
EWSAT1	High	MG63 and HOS cells	Inhibit MEG3 expression	Promote	[64]
FGFR3-AS1	High	MG63 and U2OS cells	Upregulate FGFR3 expression	Promote	[65]
PVT1	High	KHOS, 143b, LM7, U2OS, and MG63 cells	Increase BCL2 and CCND1 protein expression via negatively regulating miR-195	Promote	[66]
SNHG12	High	Saos-2, MG63 and U2OS cells	Upregulate AMOT mRNA expression	Promote	[67]
TUSC7	Low	HOS and MG63	Promote apoptosis	Inhibit	[68]
UCA1	High	HOS, Saos-2, MG63, U2OS cells	Inhibit apoptosis	Promote	[69]
MFI2	High	SAOS-2, MG63, and U2OS cells	Upregulate FOXP4	Promote	[70]
PACER	High	143B, MG63, Saos-2, U2OS cells	Activate NF-κB-dependent COX-2	Promote	[71]
HNF1A-AS1	High	HOS, SaOS2, MG63 and U2OS cells	Wnt/β-catenin pathway	Promote	[72]
BCAR4	High	MG63 and U2OS cells	Activate GLI2 pathway	Promote	[73]
ZEB1-AS1	High	HOS, U2OS, MG-63, and Saos-2 cells	Related to ZEB1 lncRNA	Promote	[74]

OS, osteosarcoma; TUG1, taurine upregulated gene 1; Chr, chromosome; Yap1, yes-associated protein 1; Hh, Hedgehog; HIF2PUT, hypoxia-inducible factor-2α (HIF-2α) promoter upstream transcript; BANCR, BRAF-regulated lncRNA 1; JNK, c-Jun N-terminal kinases; MALAT1, Metastasis-associated lung adenocarcinoma transcript 1; HOTAIR, homeobox (HOX) transcript antisense RNA; MMP, matrix metalloproteinase; ANCR, antidifferentiation noncoding RNA; PI3K, phosphatidylinositol-3-kinase; AKT, protein kinase B; EWSAT1, Ewing sarcoma–associated transcript 1; FGFR3-AS1, FGFR3 antisense transcript 1; PVT1, plasmacytoma variant translocation 1; SNHG12, small nucleolar RNA host gene 12; TUSC7, tumor suppressor candidate 7; UCA1, urothelial carcinoma associated 1; FOXP4, forkhead box P4; PACER, P50-associated COX-2 extragenic RNA; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; HNF1A-AS1, HNF1A-antisense 1; BCAR4, breast cancer anti-estrogen resistance 4; HOTTIP, HOXA Distal Transcript Antisense RNA; ROCKs, Rho-associated coiled-coil containing protein kinases; ZEB1-AS1, Zinc Finger E-Box Binding Homeobox 1 Antisense RNA 1; Ref, reference.