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Current strategies for targeting the epidermal growth factor receptor (EGFR) pathway. EGF receptors (Blue) activate survival signaling pathways including RAS/MAPK and PI3K/AKT signaling pathway leading to cell growth and proliferation. HGF/MET (green) signaling also promotes cell growth and proliferation through RAS/MAPK and STAT3 phosphorylation. Regular arrow: activates, Arrow ending with a straight line: inhibits.
