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. 2017 Apr 4;18(4):756. doi: 10.3390/ijms18040756

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of apigenin on electrocardiogram (ECG) wave forms in streptozotocin (STZ)–isoproterenol-treated rats. The red arrows indicate the deformations of normal ECG waveforms at the place of formation of P-wave and red circle indicates the changes in the QRS complex, especially the ST segment. The green circle indicates the normalization of ECG waveforms and restoration of the ST segment, while the green arrows indicate the normal appearance of the ST segment and P-wave. *** p < 0.001 compared to diabetic isoproterenol; ### p < 0.001 compared to diabetic control; $ p < 0.001 compared to diabetic isoproterenol + apigenin.