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. 2017 Apr 4;18(4):756. doi: 10.3390/ijms18040756

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of apigenin on peak positive and negative pressure development in STZ–isoproterenol-treated rats. (A) Left ventricular end diastolic pressure (LVEDP), (B) Maximal positive rate of left ventricular pressure (+LVdp/dt_max), (C) Maximal negative rate of left ventricular pressure (−LVdp/dt_min). The data are expressed as the mean ± SEM. The significance was determined by one-way ANOVA followed by the Bonferroni’s post hoc test: *** p < 0.001 compared to diabetic isoproterenol; ### p < 0.001 compared to diabetic control; $ p < 0.001 compared to diabetic isoproterenol + apigenin.