Figure 1.

Schematic representation of putative cellular targets of protein kinases C (PKCs, in red) with respect to regulation of drug transporter activity, localization and/or expression. Arrows in red indicate the putative effects of PKCs on transporter regulatory pathways. Arrows in blue correspond to the different transporter processing steps, from gene (DNA) to activity regulation at the plasma membrane by phosphorylation (P, in red). DNA: deoxyribonucleic acid; mRNA: messenger ribonucleic acid.