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. 2017 Apr 5;18(4):774. doi: 10.3390/ijms18040774

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of MPCs and macrophages between normal, pre-OA and OA synovium. No difference was observed in the number of CD90 or CD271 positive cells in the intima or subintima between normal and pre-OA knee synovium (A,B), however, decreased numbers of CD14 positive cells were observed in the subintima of pre-OA vs. normal joints. No difference in MPCs (CD90⁺ CD271⁺) was observed between normal and pre-OA synovium (C), while fewer macrophages (CD14⁺ CD68⁺) were observed in pre-OA synovium (C). Furthermore, significantly more MPCs and macrophages were observed in the synovium (intima and subintima) of OA joints compared to both normal and pre-OA (A–C). The level of synovial inflammation increased with severity of the disease (D). * p < 0.05.