Table 1.
Summary of epigenome-wide association studies in schizophrenic brain tissue.
| Main Findings (Year) | Healthy Controls (n) | Patients (n) | Reference |
|---|---|---|---|
| 2929 DMPs 1 (including NOS1, AKT1, SOX10, DTNBP1 and PPP3CC) (2014). | 24 | 24 | [50] |
| Differential expression and methylation of PIK3R1, BTN3A3, NHLH1 and SLC16A7 (2014). | 43 | 39 | [51] |
| 5 top-ranked DMPs in PFC 2: GSDMD, RASA3, HTR5A, PPFIA1, CACNA1G (2014). | 23 | 20 | [52] |
| 5 top-ranked DMPs in cerebellum: NAV1, ZNF200, PRH2, NFIA1, COL16A1 (2014). | 23 | 21 | [52] |
| 107 DMPs (Hypermethylation in 79 DMP in schizophrenic brains) (2014). | 110 | 106 | [53] |
| 1550 DMPs (Consistently DMP in schizophrenic brain: upstream or in gene regions of CERS3, DPPA5, REC8, PRDM9, LY6G5C and DDX43). (2015). | 24 | 24 | [54] |
| 139 DMPs (5 top-ranked DMPs in PFC: NUBP1, RASA3, STK32B, AIG1, PRKCE. 5 top-ranked DMPs in hippocampus: HLA-DQA1, HCN2, GPC5, SERPINA5, POLRMT). (2016). |
19 | 3 | [55] |
1 Differentially methylated positions; 2 Prefrontal cortex.