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. 2017 Apr 19;18(4):835. doi: 10.3390/ijms18040835

Figure 7.

Figure 7

Structural analysis of SAK-HV-induced RAW264.7 cell proliferation (*** p < 0.001; NS, no significance). Among the three domains of SAK-HV—SAK-mutant, RGD, and hirudin-12—only the SAK-mutant domain could induce RAW264.7 cell proliferation at a level comparable to the full SAK-HV protein. Wild-type SAK had no effects on RAW264.7 cell proliferation (n = 6). RAW264.7 cells were treated with SAK-HV, the three individual functional domains of SAK-HV or the wild type SAK at 1 μM, to determine their effects on SAK-HV-mediated proliferation via the CCK8 assays. Abbreviation: hirudin-12, a 12-amino acid peptide from the C-terminus of hirudin.