Table 2.
Responses of AEL patients treated with HMA or ICT.
| HMA All Lines (n = 75) 1 | HMA 1st Line (n = 39) 2 | HMA ≥ 2nd Line (n = 34) 3 | ICT 1st Line (n = 119) 4 | |
|---|---|---|---|---|
| Overall response acc. to ELN, n (%) | 30 (40.0) | 18 (46.2) | 10 (29.4) | 86 (72.3) |
| Complete | 20 (26.7) | 12 (30.8) | 7 (20.6) | 79 (66.4) |
| Partial | 10 (13.3) | 6 (15.4) | 3 (8.8) | 7 (5.9) |
| Overall response including HI, n (%) | 44 (58.7) | 25 (64.1) | 17 (50.0) | ND |
| HI without marrow response | 14 (18.7) | 7 (17.9) | 7 (20.6) | ND |
| ANC | 9 (12.0) | 6 (15.4) | 3 (8.8) | |
| RBC | 7 (9.3) | 5 (12.8) | 2 (5.9) | |
| PLT | 9 (12.0) | 5 (12.8) | 4 (11.8) | |
| Transfusion independence, n/n (%) 5 | ||||
| RBC-TI | 19/55 (35) | 13/32 (40.6) | 6/21 (28.6) | ND |
| PLT-TI | 8/28 (29) | 3/14 (21.4) | 4/12 (33.3) | |
| Stable disease | 26 (34.7) | 11 (28.2) | 15 (44.1) | 16 (13.4) |
| Primary disease progression | 5 (6.7) | 3 (7.7) | 2 (5.9) | 17 (14.3) |
| Time to first response, days 6 | ND | |||
| Median (min–max) | 79 (18–822) 7 | 66 (18–233) | 85 (30–822) | |
| Time to best response, days 8 | ||||
| Median (min–max) | 120 (20–1150) 7 | 143 (20–353) | 89.5 (30–1150) | ND |
1 Data available for 75 patients; 2 Data available for 39 patients; 3 Data available for 34 patients; 4 Data on HI was not assessed in this subgroup of patients, as this response form is considered irrelevant for AML-patients treated with ICT; 5 Evaluated in the subset of patients who were transfusion dependent at the start of HMA therapy; 6 Data available for 51 patients; 7 The longest time (822 days to fist response and 1150 days to best response) is a single patient. Other late responders are all ~200 days (6.6 months); and 8 Data available for 52 patients; and ND: not detected.