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A schema showing that early-life environmental insults affect the l-arginine–ADMA–NO pathway, increase oxidative stress, and dysregulate nutrient sensing signals, leading to cardiovascular programming and cardiovascular disease (CVD) in later life. Early targeting of the above mechanisms might serve as a reprogramming approach to prevent CVD and its related comorbidities in adulthood. ↑ = increased. ↓ = decreased.
