Figure 3.

Effect of folic acid on GSK-3β and PP2A peptides in STZ-treated mouse brains. Representative Western blot image of p-GSK-3β (Ser9), GSK-3β and β-actin respectively (A); Quantified results of GSK-3β was normalized to β-actin (B); Relative expression level of p-GSK-3β (Ser9) was normalized to GSK-3β expression (C); Representative Western blot image of anti-methylated, anti-demethylated and total PP2A (D); histograms showing semi-quantitative analyses of anti-methylated (E); anti-demethylated (F) and total PP2A (G). The data were expressed as means ± SD values, n = 5 animals/group. * p < 0.05 versus the DM-FN group. PP2A, protein phosphatase 2A; GSK-3β, glycogen synthase kinase 3β.