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. 2017 Apr 20;18(4):871. doi: 10.3390/ijms18040871

Figure 1.

Figure 1

Model of a migrating breast cancer cell (BCC) with reported molecular signaling pathways for LOX, SPARC, and MEMO1. (IGF, insulin growth factor; IGF-IR, insulin growth factor 1 receptor; E2, estrogen; ER, estrogen receptor; HRG, heregulin; IRS1, insulin receptor substrate 1; ERα, estrogen receptor α; PI3K, phosphoinositide 3-kinase; EMT, epithelial-mesenchymal transition; MT, microtubuli; ROS, reactive oxygen species; NOX1, NADPH oxidase 1; ECM, extracellular matrix; MMP2, matrix metalloproteinase 2; FAK, focal adhesion kinase); SHC, Src homology 2 domain containing. The arrows indicate the direction of the molecular signaling pathways.