Table 2. Univariate Analysis of Factors Associated With Relapse.

Variables	Relapses/total	P value	Hazard ratio	95% CI
Sex
Female	18/34	0.605	1
Male	41/72		1.158	0.664 - 2.017
Disease duration (months)
≤ 18	42/84	0.072	1
> 18	17/22		1.679	0.954 - 2.955
Age at diagnosis
≤ 16 years (A1)	3/10	0.071	1
17 - 40 years (A2)	46/83	0.266	1.942	0.603 - 6.255
> 40 years (A3)	10/13	0.045	3.763	1.032 - 13.719
Location
Ileum (L1)	22/36	0.267	1
Colon (L2)	5/7	0.185	1.944	0.728 - 5.188
Ileocolon (L3)	32/63	0.660	0.885	0.513 - 1.525
Upper GI (L4)	0/0
Behavior
Inflammatory (B1)	25/55	0.094	1
Stricturing (B2)	27/41	0.081	1.624	0.942 - 2.800
Penetrating (B3)	7/10	0.070	2.171	0.937 - 5.027
Perianal disease
No	45/78	0.888	1
Yes	14/28		0.957	0.524 - 1.751
Extraintestinal manifestation
No	52/96	0.168	1
Yes	7/10		1.746	0.790 - 3.858
Therapeutic regimen
Top-down	37/76	0.027	1
Step-up	22/30		1.820	1.070 - 3.093
Combine therapy
No	48/86	0.624	1
Yes	11/20		1.179	0.611 - 2.272
CD-related surgery before infusion
No	39/79	0.049	1
Yes	20/27		1.718	1.002 - 2.947
Biologic variables at week 0
Low Hb level* (n = 106)
No	14/38	0.004	1
Yes	45/68		2.419	1.325 - 4.416
Low Hct level** (n = 106)
No	17/41	0.020	1
Yes	42/65		1.955	1.112 - 3.438
CRP level (mg/L) (n = 101)
≤ 5	20/37	0.898	1
> 5	36/64		1.036	0.600 - 1.791
Alb level (g/L) (n = 102)
≥ 40	15/38	0.027	1
< 40	41/64		1.955	1.081 - 3.535
Biologic variables at week 30
Low Hb level* (n = 105)
No	33/66	0.277	1
Yes	25/39		1.335	0.793 - 2.245
Low Hct level** (n = 105)
No	28/62	0.009	1
Yes	30/43		1.992	1.188 - 3.341
CRP level (mg/L) (n = 93)
≤ 5	30/68	0.000	1
> 5	21/25		3.479	1.979 - 6.114
Alb level (g/L) (n = 99)
≥ 40	27/66	0.000	1
< 40	26/33		2.717	1.567 - 4.711
AZA after IFX discontinuation
No	14/29	0.109	1
Yes	45/77		1.644	0.896 - 3.018

CRP: C-reactive protein; Alb: albumin; Hb: hemoglobin; AZA: azathioprine; CI: confidence interval. *Male patients < 130 g/L, female patients < 115 g/L. **Male patients < 0.4, female patients < 0.35.