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. 2017 May 1;216(5):1473–1488. doi: 10.1083/jcb.201510042

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© 2017 Longmate et al.

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Figure 2. — α9β1 inhibits the α3β1-dependent secretion of keratinocyte factors that suppress endothelial cell apoptosis. (A and B) HUVEC apoptosis was measured in response to conditioned media from MK cells that express α3β1 and/or α9β1 in various combinations as indicated. (A, top) Apoptotic cells were detected by immunostaining with an antibody against cleaved caspase 3 (CC3). Bottom, DAPI staining of nuclei. Bar, 100 µm. (B) Graph showing relative caspase 3 activity in HUVECs (EnzChek assay) normalized to the daily mean to account for variability by day. Means ± SEM are shown. n = 3 independent experiments. A one-way analysis of variance with Newman-Keuls’s multiple comparisons test was used. *, P < 0.05 compared with nonasterisked groups.