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. 2017 May 1;216(5):1255–1265. doi: 10.1083/jcb.201607022

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© 2017 Poulton et al.

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Figure 4. — Centrosome/SAC loss reduces NB proliferation, but asymmetric division still occurs. (A–E) Mitotic marker PH3. There were significantly fewer dividing cells in mad2 sas-4 brains, quantified in E. Error bars represent means ± SD. (F) A single CB NB (Dpn⁺, green) generated several adjacent progeny (Pros⁺, red). (G and H) Examples of CB NBs (green) and adjacent progeny (red) in WT and mad2 sas-4, indicated by the dashed circles. (I) Still images from Video 3 of mad2 sas-4 expressing Moe:GFP and the chromatin marker His:RFP. Arrows indicate mitotic CB NBs undergoing asymmetric division to maintain the NB (I’) and to produce a smaller daughter bound for differentiation (I’’).

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