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. 2017 Mar 28;7:492. doi: 10.1038/s41598-017-00461-9

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Kidney gene expressions and hematocrit in WT and hAS^+/− mice. (A,B) hAS^+/− (AS-TG) mice showed significantly higher gene expressions of the three kidney ENaC subunits encoded by SCNN1a, SCNN1b, and SCNN1g compared to WT mice fed with either NS or HS diet. *p < 0.05. (C,D) hAS^+/− mice had significantly higher gene expressions of the kidney sodium chloride co-transporter as compared to WT mice fed with either NS or HS diet. *p < 0.05. (E) HS diet increased hematocrit in hAS^+/− but not WT mice. *p < 0.05, between AS-TG groups; ^† p < 0.05, compared to AS-TG Chow group; ^§ p < 0.05, compared to AS-TG HS group.