Table 2.
Weighted multiple linear regression to investigate the relationship between metaflammasome components and hypertension and self‐reported type 2 diabetes.
| Metaflammasome components [load (%)] | No Dementia | Dementia with AD pathology | ||||
|---|---|---|---|---|---|---|
| β | 95%CI(β) | P | β | 95%CI(β) | P | |
| Hypertension | ||||||
| IKKβ | 0.02 | (0.02; 0.03) | <0.001 | −0.03 | (−0.05; −0.02) | <0.001 |
| IRS1 | 0.04 | (0.03; 0.06) | <0.001 | −0.03 | (−0.04; −0.01) | 0.006 |
| JNK | 0.07 | (0.05; 0.09) | <0.001 | −0.05 | (−0.07; −0.03) | <0.001 |
| PKR | −0.01 | (−0.03; 0.01) | 0.281 | −0.09 | (−0.11; −0.06) | <0.001 |
| Type 2 diabetes | ||||||
| IKKβ | −0.02 | (−0.03; −0.01) | 0.004 | 0.00 | (−0.02; 0.02) | 0.793 |
| IRS1 | −0.05 | (−0.06; −0.03) | <0.001 | −0.05 | (−0.07; −0.02) | <0.001 |
| JNK | −0.05 | (−0.07; −0.04) | <0.001 | 0.10 | (0.06; 0.13) | <0.001 |
| PKR | −0.01 | (−0.04; 0.01) | 0.225 | −0.07 | (−0.11; −0.02) | 0.005 |
P‐value < 0.012 considered to indicate statistical significance according to the Bonferroni's method.
Significant positive association (dark gray); Significant negative association (light gray).