. 2016 Jun 8;27(3):266–275. doi: 10.1111/bpa.12388

Table 6.

Weighted logistic regression to investigate the relationship between metaflammasome components and Alzheimer's pathology according to disease status.

Metaflammasome components [load (%)]	Meningeal CAA	Parenchymal CAA	Diffuse plaques	Neuritic plaques	Tangles
No Dementia
IKKβ	0.00 (0.00; 0.02) <0.001 ^†	0.00 (0.00; 0.00) <0.001	0.86 (0.51; 1.45) 0.573	2.65 (1.33; 5.31) 0.006	391.08 (135.07; 1132.32) <0.001
IRS1	0.04 (0.02; 0.09) <0.001	0.00 (0.00; 0.00) <0.001	0.22 (0.15; 0.31) <0.001 ^†	0.49 (0.31; 0.79) 0.003 ^†	0.77 (0.19; 3.16) 0.714
JNK	0.11 (0.06; 0.21) <0.001	0.28 (0.14; 0.56) <0.001	1.07 (0.88; 1.31) 0.473	0.60 (0.44; 0.81) 0.001 ^†	0.00 (0.00; 0.02) <0.001
PKR	0.25 (0.14; 0.44) <0.001	1.40 (0.97; 2.03) 0.072	0.76 (0.62; 0.93) 0.008	1.10 (0.84; 1.44) 0.502	0.08 (0.05; 0.14) <0.001
Dementia with AD pathology
IKKβ	0.51 (0.26; 0.98) 0.043	1.62 (0.72; 3.64) 0.242	3.89 (1.54; 9.79) 0.004 ^†	70.24 (27.06; 182.30) <0.001 ^†	5.26 (2.92; 9.48) <0.001
IRS1	0.79 (0.45; 1.38) 0.403	1.21 (0.64; 2.30) 0.555	1.66 (0.93; 2.95) 0.087	5.07 (2.75; 9.34) <0.001	1.34 (0.81; 2.21) 0.260
JNK	8.98 (5.66; 14.25) <0.001 ^†	10.93 (6.46; 18.47) <0.001 ^†	3.11 (1.95; 4.96) <0.001	5.96 (3.94; 9.01) <0.001 ^†	1.09 (0.74; 1.61) 0.650
PKR	3.63 (2.74; 4.83) <0.001	7.35 (5.22; 10.35) <0.001 ^†	4.23 (3.08; 5.82) <0.001	1.95 (1.52; 2.49) <0.001	1.68 (1.27; 2.21) <0.001

Metaflammasome components [load (%)]

Meningeal CAA

Parenchymal CAA

Diffuse plaques

Neuritic plaques

Tangles

OR [95%CI(OR)]P

No Dementia

IKKβ

0.00 (0.00; 0.02)

<0.001 ^†

0.00 (0.00; 0.00)

<0.001

0.86 (0.51; 1.45)

0.573

2.65 (1.33; 5.31)

0.006

391.08 (135.07; 1132.32)

<0.001

IRS1

0.04 (0.02; 0.09)

<0.001

0.00 (0.00; 0.00)

<0.001

0.22 (0.15; 0.31)

<0.001 ^†

0.49 (0.31; 0.79)

0.003 ^†

0.77 (0.19; 3.16)

0.714

JNK

0.11 (0.06; 0.21)

<0.001

0.28 (0.14; 0.56)

<0.001

1.07 (0.88; 1.31)

0.473

0.60 (0.44; 0.81)

0.001 ^†

0.00 (0.00; 0.02)

<0.001

PKR

0.25 (0.14; 0.44)

<0.001

1.40 (0.97; 2.03)

0.072

0.76 (0.62; 0.93)

0.008

1.10 (0.84; 1.44)

0.502

0.08 (0.05; 0.14)

<0.001

Dementia with AD pathology

IKKβ

0.51 (0.26; 0.98)

0.043

1.62 (0.72; 3.64)

0.242

3.89 (1.54; 9.79)

0.004 ^†

70.24 (27.06; 182.30)

<0.001 ^†

5.26 (2.92; 9.48)

<0.001

IRS1

0.79 (0.45; 1.38)

0.403

1.21 (0.64; 2.30)

0.555

1.66 (0.93; 2.95)

0.087

5.07 (2.75; 9.34)

<0.001

1.34 (0.81; 2.21)

0.260

JNK

8.98 (5.66; 14.25)

<0.001 ^†

10.93 (6.46; 18.47)

<0.001 ^†

3.11 (1.95; 4.96)

<0.001

5.96 (3.94; 9.01)

<0.001 ^†

1.09 (0.74; 1.61)

0.650

PKR

3.63 (2.74; 4.83)

<0.001

7.35 (5.22; 10.35)

<0.001 ^†

4.23 (3.08; 5.82)

<0.001

1.95 (1.52; 2.49)

<0.001

1.68 (1.27; 2.21)

<0.001

P‐value < 0.012 considered to indicate statistical significance according to the Bonferroni's method.

^†Significant positive association (dark gray) and significant negative association (light gray) with the relationship maintained in the sensitivity analysis.